DGKA

DGKA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1TUZ
Dynodwyr
Cyfenwau	DGKA, DAGK, DAGK1, DGK-alpha, diacylglycerol kinase alpha
Dynodwyr allanol	OMIM: 125855 HomoloGene: 1028 GeneCards: DGKA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • calcium ion binding • phospholipid binding • ATP binding • metal ion binding • kinase activity • diacylglycerol kinase activity • NAD+ kinase activity Cydrannau o'r gell • cytosol • Cellbilen • bilen • intracellular anatomical structure Prosesau biolegol • platelet activation • protein kinase C-activating G protein-coupled receptor signaling pathway • GO:0007243 intracellular signal transduction • phosphorylation • glycerolipid metabolic process • phosphatidic acid biosynthetic process • diacylglycerol metabolic process • lipid phosphorylation • metabolaeth • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1606	n/a
Ensembl	ENSG00000065357	n/a
UniProt	P23743	n/a
RefSeq (mRNA)	NM_001345 NM_201444 NM_201445 NM_201554 NM_001351033 NM_001351034 NM_001351035 NM_001351036 NM_001351037 NM_001351038 NM_001351039 NM_001351040	n/a
RefSeq (protein)	NP_001336 NP_958852 NP_958853 NP_963848 NP_001337962 NP_001337963 NP_001337964 NP_001337965 NP_001337966 NP_001337967 NP_001337968 NP_001337969	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DGKA yw DGKA a elwir hefyd yn Diacylglycerol kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DGKA.

• DAGK
• DAGK1
• DGK-alpha

Llyfryddiaeth

• "Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression. ". J Cell Physiol. 2017. PMID 27731506.
• "Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. ". Nat Commun. 2016. PMID 26964756.
• "Molecular Pathways: Targeting Diacylglycerol Kinase Alpha in Cancer. ". Clin Cancer Res. 2015. PMID 26420856.
• "High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention. ". J Immunol. 2012. PMID 22573804.
• "Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway.". J Hepatol. 2012. PMID 22425622.