DDB2

DDB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3EI4, 3I7L, 4E54, 4E5Z
Dynodwyr
Cyfenwau	DDB2, DDBB, UV-XPE, damage specific DNA binding protein 2
Dynodwyr allanol	OMIM: 600811 HomoloGene: 83 GeneCards: DDB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • damaged DNA binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • nucleoplasm • cell junction • Cul4B-RING E3 ubiquitin ligase complex • cnewyllyn cell • Cul4-RING E3 ubiquitin ligase complex • GO:0009327 protein-containing complex Prosesau biolegol • nucleotide-excision repair • pyrimidine dimer repair • nucleotide-excision repair, DNA damage recognition • histone H2A monoubiquitination • protein polyubiquitination • cellular response to DNA damage stimulus • global genome nucleotide-excision repair • protein ubiquitination • nucleotide-excision repair, DNA incision • UV-damage excision repair • response to UV • GO:0100026 DNA repair • protein autoubiquitination • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, preincision complex stabilization • nucleotide-excision repair, preincision complex assembly • protein deubiquitination • post-translational protein modification • response to UV-B • nucleotide-excision repair, DNA duplex unwinding • nucleotide-excision repair, DNA incision, 3'-to lesion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1643	n/a
Ensembl	ENSG00000134574	n/a
UniProt	Q92466	n/a
RefSeq (mRNA)	NM_000107 NM_001300734	n/a
RefSeq (protein)	NP_000098 NP_001287663	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DDB2 yw DDB2 a elwir hefyd yn Damage specific DNA binding protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DDB2.

• XPE
• DDBB
• UV-DDB2

Llyfryddiaeth

• "UV radiation-induced SUMOylation of DDB2 regulates nucleotide excision repair. ". Carcinogenesis. 2017. PMID 28981631.
• "DDB2 (damaged-DNA binding 2) protein: a new modulator of nanomechanical properties and cell adhesion of breast cancer cells. ". Nanoscale. 2016. PMID 26879405.
• "The 5'-UTR of DDB2 harbors an IRES element and upregulates translation during stress conditions. ". Gene. 2015. PMID 26187069.
• "DDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer. ". Mol Cancer Res. 2014. PMID 24574518.
• "A novel DDB2-ATM feedback loop regulates human cytomegalovirus replication.". J Virol. 2014. PMID 24335308.