CYP2C8

CYP2C8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2VN0, 1PQ2, 2NNH, 2NNI, 2NNJ
Dynodwyr
Cyfenwau	CYP2C8, CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM
Dynodwyr allanol	OMIM: 601129 HomoloGene: 117948 GeneCards: CYP2C8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • caffeine oxidase activity • aromatase activity • oxidoreductase activity • heme binding • metal ion binding • iron ion binding • arachidonic acid epoxygenase activity • monooxygenase activity • estrogen 16-alpha-hydroxylase activity • steroid hydroxylase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Cydrannau o'r gell • Reticwlwm endoplasmig • organelle membrane • bilen • intracellular membrane-bounded organelle • endoplasmic reticulum membrane • cytoplasm Prosesau biolegol • omega-hydroxylase P450 pathway • organic acid metabolic process • epoxygenase P450 pathway • oxidative demethylation • xenobiotic metabolic process • lipid hydroxylation • steroid metabolic process • long-chain fatty acid biosynthetic process • estrogen metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1558	n/a
Ensembl	ENSG00000138115	n/a
UniProt	P10632	n/a
RefSeq (mRNA)	NM_000770 NM_001198853 NM_001198854 NM_001198855 NM_030878	n/a
RefSeq (protein)	NP_000761 NP_001185782 NP_001185783 NP_001185784	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP2C8 yw CYP2C8 a elwir hefyd yn Cytochrome P450 family 2 subfamily C member 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q23.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP2C8.

• CPC8
• CYPIIC8
• MP-12/MP-20

Llyfryddiaeth

• "Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8). ". J Med Chem. 2017. PMID 28653847.
• "Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. ". Arterioscler Thromb Vasc Biol. 2016. PMID 27417579.
• "Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6α-hydroxylation and amodiaquine N-deethylation. ". Drug Metab Pharmacokinet. 2015. PMID 26427316.
• "Gender-Specific Effect of CYP2C8*3 on the Risk of Essential Hypertension in Bulgarian Patients. ". Biochem Genet. 2015. PMID 26404779.
• "Impact of CYP2C8*3 polymorphism on in vitro metabolism of imatinib to N-desmethyl imatinib.". Xenobiotica. 2016. PMID 26161459.