CYP17A1

CYP17A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3RUK, 3SWZ, 4NKV, 4NKW, 4NKX, 4NKY, 4NKZ
Dynodwyr
Cyfenwau	CYP17A1, CPT7, CYP17, P450C17, S17AH, cytochrome P450 family 17 subfamily A member 1
Dynodwyr allanol	OMIM: 609300 HomoloGene: 73875 GeneCards: CYP17A1
EC number	1.14.14.32 1.14.14.19, 1.14.14.32
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • oxygen binding • metal ion binding • steroid 17-alpha-monooxygenase activity • monooxygenase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • lyase activity • oxidoreductase activity • 17-alpha-hydroxyprogesterone aldolase activity Cydrannau o'r gell • endoplasmic reticulum membrane • bilen • axon • neuronal cell body • Reticwlwm endoplasmig Prosesau biolegol • progesterone metabolic process • androgen biosynthetic process • glucocorticoid biosynthetic process • sterol metabolic process • hormone biosynthetic process • steroid biosynthetic process • steroid metabolic process • sex differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1586	n/a
Ensembl	ENSG00000148795	n/a
UniProt	P05093	n/a
RefSeq (mRNA)	NM_000102	n/a
RefSeq (protein)	NP_000093	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP17A1 yw CYP17A1 a elwir hefyd yn Cytochrome P450 family 17 subfamily A member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q24.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP17A1.

• CPT7
• CYP17
• S17AH
• P450C17

Llyfryddiaeth

• "Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production. ". Biochemistry. 2016. PMID 27426448.
• "Common Genetic Variation in CYP17A1 and Response to Abiraterone Acetate in Patients with Metastatic Castration-Resistant Prostate Cancer. ". Int J Mol Sci. 2016. PMID 27409606.
• "Specificity of anti-prostate cancer CYP17A1 inhibitors on androgen biosynthesis. ". Biochem Biophys Res Commun. 2016. PMID 27395338.
• "Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN. ". J Biol Chem. 2016. PMID 27339894.
• "Clinical and molecular manifestation of fifteen 17OHD patients: a novel mutation and a founder effect.". Endocrine. 2016. PMID 27150612.