CXCL8

CXCL8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3IL8, 1ICW, 1IKL, 1IKM, 1IL8, 1ILP, 1ILQ, 1QE6, 1ROD, 2IL8, 4XDX
Dynodwyr
Cyfenwau	CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8, SCYB8
Dynodwyr allanol	OMIM: 146930 HomoloGene: 47937 GeneCards: CXCL8
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytokine activity; • GO:0001948, GO:0016582 protein binding; • interleukin-8 receptor binding; • chemokine activity;
Cydrannau o'r gell	• extracellular region; • intracellular anatomical structure; • extracellular space;
Prosesau biolegol	• G protein-coupled receptor signaling pathway; • GO:0007243 intracellular signal transduction; • chemokine-mediated signaling pathway; • cellular response to tumor necrosis factor; • receptor internalization; • cellular response to fibroblast growth factor stimulus; • response to endoplasmic reticulum stress; • positive regulation of angiogenesis; • regulation of single stranded viral RNA replication via double stranded DNA intermediate; • PERK-mediated unfolded protein response; • induction of positive chemotaxis; • chemotaxis; • regulation of cell adhesion; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • cellular response to interleukin-1; • angiogenesis; • positive regulation of neutrophil chemotaxis; • inflammatory response; • negative regulation of G protein-coupled receptor signaling pathway; • response to molecule of bacterial origin; • cellular response to lipopolysaccharide; • embryonic digestive tract development; • GO:0072468 signal transduction; • negative regulation of cell population proliferation; • calcium-mediated signaling; • regulation of entry of bacterium into host cell; • defense response; • neutrophil chemotaxis; • neutrophil activation; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • cytokine-mediated signaling pathway; • leukocyte chemotaxis;
	Sources:Amigo / QuickGO
Orthologau
	3576
	n/a
	ENSG00000169429
	n/a
	P10145
	n/a
	NM_000584; NM_001354840
	n/a
	NP_000575; NP_001341769
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CXCL8 yw CXCL8 a elwir hefyd yn C-X-C motif chemokine ligand 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CXCL8.

IL8
NAF
GCP1
LECT
LUCT
NAP1
GCP-1
LYNAP
MDNCF
MONAP
NAP-1

Llyfryddiaeth

"Streptococcus gordonii lipoproteins induce IL-8 in human periodontal ligament cells. ". Mol Immunol. 2017. PMID 28963931.
"Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model. ". Int J Cancer. 2018. PMID 28949016.
"CXCL8 promotes the invasion of human osteosarcoma cells by regulation of PI3K/Akt signaling pathway. ". APMIS. 2017. PMID 28736978.
"Association between interleukin-8 levels and chronic periodontal disease: A PRISMA-compliant systematic review and meta-analysis. ". Medicine (Baltimore). 2017. PMID 28562542.
"IL-8 -251A/T polymorphism contributes to coronary artery disease susceptibility in a Chinese population.". Genet Mol Res. 2017. PMID 28218776.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CXCL8 - Cronfa NCBI

[1]

[2]