CREB1

CREB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2LXT
Dynodwyr
Cyfenwau	CREB1, CREB, CREB-1, cAMP responsive element binding protein 1
Dynodwyr allanol	OMIM: 123810 HomoloGene: 3223 GeneCards: CREB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • cAMP response element binding • GO:0001104 transcription coregulator activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • enzyme binding • GO:0001948, GO:0016582 protein binding • double-stranded DNA binding • DNA binding • sequence-specific DNA binding • identical protein binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • Hsp70 protein binding • histone acetyltransferase binding • arrestin family protein binding Cydrannau o'r gell • mitocondria • cnewyllyn cell • ATF4-CREB1 transcription factor complex • chromatin • transcription regulator complex • nucleoplasm • axon • mitochondrial matrix Prosesau biolegol • cellular response to nerve growth factor stimulus • positive regulation of lipid biosynthetic process • positive regulation of long-term synaptic potentiation • proses rythmig • cellular response to insulin-like growth factor stimulus • transcription by RNA polymerase II • response to organic substance • mammary gland development • protein phosphorylation • type I pneumocyte differentiation • Rhythm circadaidd • positive regulation of multicellular organism growth • response to L-glutamate • lung saccule development • lung epithelium development • transforming growth factor beta receptor signaling pathway • regulation of apoptotic process • cellular response to transforming growth factor beta stimulus • response to glucagon • GO:0009373 regulation of transcription, DNA-templated • negative regulation of transcription by competitive promoter binding • response to nicotine • positive regulation of osteoclast differentiation • Cof • negative regulation of gene expression • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • lactation • positive regulation of transforming growth factor beta3 production • GO:0022415 viral process • positive regulation of fat cell differentiation • negative regulation of neuron death • cell differentiation • cellular response to hepatocyte growth factor stimulus • protein stabilization • cellular response to platelet-derived growth factor stimulus • regulation of circadian rhythm • secretory granule organization • regulation of glial cell proliferation • visual learning • regulation of cell size • pituitary gland development • positive regulation of RNA polymerase II transcription preinitiation complex assembly • response to hypoxia • axonogenesis • regulation of fibroblast proliferation • cellular response to growth factor stimulus • GO:0010260 heneiddio • chemotaxis to arachidonic acid • response to activity • cellular response to zinc ion • cellular response to fatty acid • positive regulation of apoptotic process • positive regulation of hormone secretion • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of cardiac muscle tissue development • cellular response to leukemia inhibitory factor • cellular response to retinoic acid Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1385	n/a
Ensembl	ENSG00000118260	n/a
UniProt	P16220	n/a
RefSeq (mRNA)	NM_004379 NM_134442 NM_001320793 NM_001371426 NM_001371427 NM_001371428	n/a
RefSeq (protein)	NP_001307722 NP_004370 NP_604391 NP_001358355 NP_001358356 NP_001358357	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CREB1 yw CREB1 a elwir hefyd yn Cyclic AMP-responsive element-binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q33.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CREB1.

• CREB
• CREB-1

Llyfryddiaeth

• "RhoA inhibits the hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes via positively regulating the CREB phosphorylation. ". Biosci Rep. 2017. PMID 28254846.
• "CREB knockdown inhibits growth and induces apoptosis in human pre-B acute lymphoblastic leukemia cells through inhibition of prosurvival signals. ". Biomed Pharmacother. 2017. PMID 28063408.
• "Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection. ". Mol Cell Biochem. 2017. PMID 27816995.
• "Downregulation of CREB Promotes Cell Proliferation by Mediating G1/S Phase Transition in Hodgkin Lymphoma. ". Oncol Res. 2016. PMID 27458098.
• "Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication In Vitro and Skin Pathogenesis In Vivo.". J Virol. 2016. PMID 27440893.