CIB1

CIB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DGU, 1DGV, 1XO5, 1Y1A, 2L4H, 2L4I, 2LM5
Dynodwyr
Cyfenwau	CIB1, CIB, CIBP, KIP1, PRKDCIP, SIP2-28, calcium and integrin binding 1
Dynodwyr allanol	OMIM: 602293 HomoloGene: 4654 GeneCards: CIB1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein serine/threonine kinase inhibitor activity; • calcium ion binding; • protein-membrane adaptor activity; • transmembrane transporter binding; • metal ion binding; • protein C-terminus binding; • GO:0001948, GO:0016582 protein binding; • calcium-dependent protein kinase inhibitor activity; • protein kinase binding;
Cydrannau o'r gell	• cytoplasm; • fesigl; • Golgi apparatus; • cell projection; • centrosome; • bilen; • growth cone; • Cellbilen; • nucleoplasm; • microtubule organizing center; • ruffle membrane; • axon; • filopodium tip; • dendrite; • neuronal cell body; • apical plasma membrane; • Reticwlwm endoplasmig; • perinuclear region of cytoplasm; • neuron projection; • sarcolemma; • extracellular exosome; • Cytosgerbwd; • cnewyllyn cell; • cyrion cell; • lamellipodium;
Prosesau biolegol	• GO:0033128 negative regulation of protein phosphorylation; • positive regulation of protein targeting to membrane; • thrombopoietin-mediated signaling pathway; • negative regulation of protein kinase B signaling; • cell differentiation; • cellular response to nerve growth factor stimulus; • positive regulation of protein phosphorylation; • negative regulation of neuron projection development; • regulation of cell division; • positive regulation of cell migration involved in sprouting angiogenesis; • extrinsic apoptotic signaling pathway; • positive regulation of cell-matrix adhesion; • positive regulation of cell migration; • cellular response to growth factor stimulus; • cellular response to tumor necrosis factor; • platelet formation; • negative regulation of apoptotic process; • negative regulation of megakaryocyte differentiation; • positive regulation of protein serine/threonine kinase activity; • positive regulation of calcineurin-NFAT signaling cascade; • Cellraniad; • cellular response to DNA damage stimulus; • negative regulation of microtubule depolymerization; • positive regulation of substrate adhesion-dependent cell spreading; • positive regulation of cell growth; • response to ischemia; • cell adhesion; • regulation of cell population proliferation; • positive regulation of NF-kappaB transcription factor activity; • double-strand break repair; • angiogenesis; • spermatogenesis; • positive regulation of cell population proliferation; • spermatid development; • positive regulation of ERK1 and ERK2 cascade; • cytoplasmic microtubule organization; • endomitotic cell cycle; • cell cycle; • positive regulation of cell adhesion mediated by integrin; • positive regulation of male germ cell proliferation; • negative regulation of cell population proliferation; • GO:0097285 apoptotic process; • GO:0048554 positive regulation of catalytic activity; • negative regulation of protein kinase activity; • negative regulation of protein serine/threonine kinase activity; • positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologau
	10519
	n/a
	ENSG00000185043
	n/a
	Q99828
	n/a
	NM_001277764; NM_006384
	n/a
	NP_001264693; NP_006375
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CIB1 yw CIB1 a elwir hefyd yn Calcium and integrin binding 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q26.1.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CIB1.

CIB
CIBP
KIP1
PRKDCIP
SIP2-28

Llyfryddiaeth[golygu | golygu cod]

"Calcium- and integrin-binding protein-1 and calcineurin are upregulated in the right atrial myocardium of patients with atrial fibrillation. ". Europace. 2012. PMID 22547769.
"Proteomic identification of CIB1 as a potential diagnostic factor in hepatocellular carcinoma. ". J Biosci. 2011. PMID 21857112.
"The Emerging Roles of CIB1 in Cancer. ". Cell Physiol Biochem. 2017. PMID 29017172.
"CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer. ". Breast Cancer Res Treat. 2015. PMID 26105795.
"Profiling of autoantibodies in sera of pancreatic cancer patients.". Ann Surg Oncol. 2014. PMID 24585405.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] CIB1 - Cronfa NCBI

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[2]