CHI3L1

CHI3L1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HJV, 1HJW, 1HJX, 1NWR, 1NWS, 1NWT, 1NWU
Dynodwyr
Cyfenwau	CHI3L1, chitinase 3-like 1 (cartilage glycoprotein-39), ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39, chitinase 3 like 1, YK-40
Dynodwyr allanol	OMIM: 601525 HomoloGene: 55569 GeneCards: CHI3L1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • chitinase activity • extracellular matrix structural constituent • rhwymyn chitin • carbohydrate binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • Reticwlwm endoplasmig • perinuclear region of cytoplasm • extracellular exosome • extracellular region • extracellular space • specific granule lumen • cytoplasm • GO:0005578 extracellular matrix Prosesau biolegol • positive regulation of protein kinase B signaling • response to interleukin-1 • response to interleukin-6 • lung development • cellular response to tumor necrosis factor • response to mechanical stimulus • activation of NF-kappaB-inducing kinase activity • positive regulation of angiogenesis • response to tumor necrosis factor • cartilage development • positive regulation of peptidyl-threonine phosphorylation • cellular response to interleukin-1 • positive regulation of ERK1 and ERK2 cascade • inflammatory response • GO:0097285 apoptotic process • neutrophil degranulation • proses catabolig chitin • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1116	n/a
Ensembl	ENSG00000133048	n/a
UniProt	P36222	n/a
RefSeq (mRNA)	NM_001276	n/a
RefSeq (protein)	NP_001267 NP_001267.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHI3L1 yw CHI3L1 a elwir hefyd yn Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHI3L1.

• GP39
• ASRT7
• GP-39
• YKL40
• CGP-39
• YKL-40
• YYL-40
• HC-gp39
• HCGP-3P
• hCGP-39

Llyfryddiaeth

• "YKL-40 and cytokines - a New Diagnostic Constellation in Rheumatoid Arthritis?". Folia Med (Plovdiv). 2017. PMID 28384116.
• "Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1. ". Oncogene. 2017. PMID 28368410.
• "Chitinase 3-like-1 deficient donor splenocytes accentuated the pathogenesis of acute graft-versus-host diseases through regulating T cell expansion and type I inflammation. ". Int Immunopharmacol. 2017. PMID 28324830.
• "Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms with Hepatocellular Carcinoma in Taiwan. ". Int J Med Sci. 2017. PMID 28260989.
• "Inhibition of Mammalian Glycoprotein YKL-40: IDENTIFICATION OF THE PHYSIOLOGICAL LIGAND.". J Biol Chem. 2017. PMID 28053085.