CDK5R1

CDK5R1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H4L, 1UNG, 1UNH, 1UNL, 3O0G
Dynodwyr
Cyfenwau	CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5, regulatory subunit 1 (p35), cyclin dependent kinase 5 regulatory subunit 1
Dynodwyr allanol	OMIM: 603460 HomoloGene: 31200 GeneCards: CDK5R1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein kinase activity • calcium ion binding • ephrin receptor binding • cadherin binding • GO:0016534 cyclin-dependent protein serine/threonine kinase activator activity • kinase activity • GO:0001948, GO:0016582 protein binding • protein kinase binding • protein serine/threonine kinase activator activity • protease binding • actin binding • ionotropic glutamate receptor binding • alpha-tubulin binding • beta-tubulin binding • actin filament binding • protein kinase activator activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • GO:0097483, GO:0097481 postsynaptic density • intracellular membrane-bounded organelle • growth cone • neuromuscular junction • dendritic spine • axon • neuronal cell body • dendrite • protein kinase 5 complex • perinuclear region of cytoplasm • contractile fiber • cnewyllyn cell • nucleoplasm • Cellbilen • microtubule • neuron projection • presynapse Prosesau biolegol • positive regulation of protein kinase activity • regulation of neuron differentiation • G protein-coupled acetylcholine receptor signaling pathway • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of actin cytoskeleton organization • embryo development • proses rythmig • ephrin receptor signaling pathway • neuron cell-cell adhesion • regulation of microtubule cytoskeleton organization • neuron migration • cerebellum development • positive regulation of protein serine/threonine kinase activity • positive regulation of neuron apoptotic process • brain development • ionotropic glutamate receptor signaling pathway • layer formation in cerebral cortex • GO:0035404 peptidyl-serine phosphorylation • neuron differentiation • cell population proliferation • peptidyl-threonine phosphorylation • GO:0045996 negative regulation of transcription, DNA-templated • neuron projection development • cerebral cortex radially oriented cell migration • axonal fasciculation • hippocampus development • negative regulation of axon extension • regulation of dendritic spine morphogenesis • regulation of macroautophagy • superior olivary nucleus maturation • positive regulation of protein targeting to membrane • axon guidance • regulation of signal transduction by p53 class mediator • serine phosphorylation of STAT protein • microtubule cytoskeleton organization • embryo development ending in birth or egg hatching • positive regulation of microtubule polymerization • positive regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of synaptic vesicle cycle • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8851	n/a
Ensembl	ENSG00000176749	n/a
UniProt	Q15078	n/a
RefSeq (mRNA)	NM_003885	n/a
RefSeq (protein)	NP_003876	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDK5R1 yw CDK5R1 a elwir hefyd yn Cyclin dependent kinase 5 regulatory subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDK5R1.

• p23
• p25
• p35
• CDK5R
• NCK5A
• CDK5P35
• p35nck5a

Llyfryddiaeth

• "The involvement of Cdk5 activator p35 in social isolation-triggered onset of early Alzheimer's disease-related cognitive deficit in the transgenic mice. ". Neuropsychopharmacology. 2011. PMID 21544067.
• "The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability. ". BMC Mol Biol. 2007. PMID 18053171.
• "CDK5 and its activator P35 in normal pituitary and in pituitary adenomas: relationship to VEGF expression. ". Int J Biol Sci. 2014. PMID 24550687.
• "p10, the N-terminal domain of p35, protects against CDK5/p25-induced neurotoxicity. ". Proc Natl Acad Sci U S A. 2012. PMID 23151508.
• "Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.". Brain. 2011. PMID 21772061.