CASP8

CASP8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1F9E, 1I4E, 1QDU, 1QTN, 2C2Z, 2FUN, 2K7Z, 2Y1L, 3H11, 3KJN, 3KJQ, 4JJ7, 4PRZ, 4PS1, 4ZBW
Dynodwyr
Cyfenwau	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5, caspase 8
Dynodwyr allanol	OMIM: 601763 HomoloGene: 7657 GeneCards: CASP8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • death effector domain binding • cysteine-type peptidase activity • cysteine-type endopeptidase activity involved in apoptotic signaling pathway • scaffold protein binding • GO:0001948, GO:0016582 protein binding • identical protein binding • cysteine-type endopeptidase activity involved in apoptotic process • cysteine-type endopeptidase activity • hydrolase activity • ubiquitin protein ligase binding • GO:0070122 peptidase activity • cysteine-type endopeptidase activity involved in execution phase of apoptosis • death receptor binding • tumor necrosis factor receptor binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cell body • cytosol • CD95 death-inducing signaling complex • ripoptosome • nucleoplasm • mitochondrial outer membrane • death-inducing signaling complex • membrane raft • neuron projection • Cytosgerbwd • cytoplasm • mitocondria • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • regulation of apoptotic process • response to estradiol • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • GO:1904576 response to antibiotic • regulation of tumor necrosis factor-mediated signaling pathway • positive regulation of macrophage differentiation • GO:1904579 cellular response to organic cyclic compound • natural killer cell activation • negative regulation of I-kappaB kinase/NF-kappaB signaling • TRAIL-activated apoptotic signaling pathway • proteolysis • macrophage differentiation • TRIF-dependent toll-like receptor signaling pathway • response to tumor necrosis factor • B cell activation • cell surface receptor signaling pathway • response to lipopolysaccharide • cellular response to mechanical stimulus • activation of cysteine-type endopeptidase activity • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • death-inducing signaling complex assembly • positive regulation of proteolysis • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • response to cold • regulation of extrinsic apoptotic signaling pathway via death domain receptors • GO:0022415 viral process • response to ethanol • response to cobalt ion • activation of cysteine-type endopeptidase activity involved in apoptotic process • proteolysis involved in cellular protein catabolic process • syncytiotrophoblast cell differentiation involved in labyrinthine layer development • nucleotide-binding oligomerization domain containing signaling pathway • T cell activation • suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process • GO:0097285 apoptotic process • extrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • regulation of necroptotic process • execution phase of apoptosis • toll-like receptor 3 signaling pathway • positive regulation of neuron death • extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of interleukin-1 beta production Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	841	n/a
Ensembl	ENSG00000064012	n/a
UniProt	Q14790	n/a
RefSeq (mRNA)	NM_001080124 NM_001080125 NM_001228 NM_033355 NM_033356 NM_033357 NM_033358 NM_001372051	n/a
RefSeq (protein)	NP_001073593 NP_001073594 NP_001219 NP_203519 NP_203520 NP_203522 NP_001358980	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CASP8 yw CASP8 a elwir hefyd yn Caspase-8 a Caspase 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q33.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CASP8.

• CAP4
• MACH
• MCH5
• FLICE
• ALPS2B
• Casp-8

Llyfryddiaeth

• "Q482H mutation of procaspase-8 in acute myeloid leukemia abolishes caspase-8-mediated apoptosis by impairing procaspase-8 dimerization. ". Biochem Biophys Res Commun. 2018. PMID 29191655.
• "Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants. ". PLoS One. 2017. PMID 28985224.
• "DNA methylation-mediated caspase-8 downregulation is associated with anti-apoptotic activity and human malignant glioma grade. ". Int J Mol Med. 2017. PMID 28204824.
• "Articulatin-D induces apoptosis via activation of caspase-8 in acute T-cell leukemia cell line. ". Mol Cell Biochem. 2017. PMID 27868169.
• "Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.". BMC Cancer. 2016. PMID 27507139.