CASC3

CASC3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HYI, 2J0Q, 2J0S, 2J0U, 2XB2, 3EX7
Dynodwyr
Cyfenwau	CASC3, BTZ, MLN51, cancer susceptibility candidate 3, cancer susceptibility 3, exon junction complex subunit, CASC3 exon junction complex subunit
Dynodwyr allanol	OMIM: 606504 HomoloGene: 7208 GeneCards: CASC3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding • ubiquitin protein ligase binding • RNA binding Cydrannau o'r gell • cytoplasm • cytosol • nuclear speck • exon-exon junction complex • perinuclear region of cytoplasm • cnewyllyn cell • nucleoplasm • nuclear membrane • cytoplasmic stress granule • dendrite • cytoplasmic ribonucleoprotein granule • cell projection • ribonucleoprotein complex • U2-type catalytic step 1 spliceosome • spliceosomal complex Prosesau biolegol • mRNA transport • mRNA processing • intracellular mRNA localization • RNA splicing • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • regulation of translation • mRNA splicing, via spliceosome • RNA export from nucleus • termination of RNA polymerase II transcription • mRNA export from nucleus • mRNA 3'-end processing • GO:0015915 transport • GO:0022610 proses fiolegol Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	22794	n/a
Ensembl	ENSG00000108349	n/a
UniProt	O15234	n/a
RefSeq (mRNA)	NM_007359	n/a
RefSeq (protein)	NP_031385	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CASC3 yw CASC3 a elwir hefyd yn Protein CASC3 a Cancer susceptibility 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CASC3.

• BTZ
• MLN51

Llyfryddiaeth

• "Targets of gene amplification and overexpression at 17q in gastric cancer. ". Cancer Res. 2002. PMID 11980659.
• "EJC core component MLN51 interacts with eIF3 and activates translation. ". Proc Natl Acad Sci U S A. 2013. PMID 23530232.
• "Metastatic lymph node 51 and fibroblast-like synoviocyte hyperproliferation in rheumatoid arthritis pathogenesis. ". Rheumatol Int. 2011. PMID 21327427.
• "The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly. ". J Cell Sci. 2007. PMID 17652158.
• "Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.". RNA. 2006. PMID 16495234.