BRCA1 Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JM7 , 1JNX , 1N5O , 1OQA , 1T15 , 1T29 , 1T2U , 1T2V , 1Y98 , 2ING , 3COJ , 3K0H , 3K0K , 3K15 , 3PXA , 3PXB , 3PXC , 3PXD , 3PXE , 4IFI , 4IGK , 4JLU , 4OFB , 4U4A , 4Y18 , 4Y2G
Dynodwyr Cyfenwau BRCA1 Dynodwyr allanol OMIM: 113705 HomoloGene: 5276 GeneCards: BRCA1 Ontoleg y genyn Gweithrediad moleciwlaidd • tubulin binding • metal ion binding • enzyme binding • zinc ion binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • GO:0001105 transcription coactivator activity • androgen receptor binding • RNA binding • ubiquitin protein ligase binding • GO:0050372 ubiquitin-protein transferase activity • DNA binding • transferase activity • RNA polymerase binding • identical protein binding Cydrannau o'r gell • BRCA1-BARD1 complex • condensed nuclear chromosome • BRCA1-A complex • ubiquitin ligase complex • Cellbilen • nucleoplasm • condensed chromosome • cytoplasm • Cromosom • cnewyllyn cell • lateral element • GO:0009327 protein-containing complex • ribonucleoprotein complex Prosesau biolegol • response to ionizing radiation • centrosome cycle • chromosome segregation • protein K6-linked ubiquitination • intrinsic apoptotic signaling pathway in response to DNA damage • cell cycle • double-strand break repair via nonhomologous end joining • GO:0097285 apoptotic process • regulation of apoptotic process • regulation of gene expression by genetic imprinting • GO:0009373 regulation of transcription, DNA-templated • negative regulation of fatty acid biosynthetic process • transcription, DNA-templated • regulation of transcription by RNA polymerase III • fatty acid biosynthetic process • regulation of DNA methylation • negative regulation of intracellular estrogen receptor signaling pathway • protein autoubiquitination • positive regulation of histone H3-K9 methylation • DNA recombination • positive regulation of angiogenesis • response to estrogen • cellular response to indole-3-methanol • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of protein ubiquitination • androgen receptor signaling pathway • negative regulation of centriole replication • postreplication repair • lipid metabolism • cellular response to tumor necrosis factor • GO:1900404 positive regulation of DNA repair • fatty acid metabolic process • GO:1901313 positive regulation of gene expression • negative regulation of histone H3-K4 methylation • regulation of cell population proliferation • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of histone H4-K20 methylation • DNA double-strand break processing • double-strand break repair via homologous recombination • negative regulation of histone acetylation • protein ubiquitination • positive regulation of histone H3-K4 methylation • GO:0100026 DNA repair • double-strand break repair • positive regulation of histone acetylation • dosage compensation by inactivation of X chromosome • negative regulation of histone H3-K9 methylation • positive regulation of histone H3-K9 acetylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • chordate embryonic development • positive regulation of histone H4-K16 acetylation • cellular response to DNA damage stimulus • protein deubiquitination • DNA replication • mitotic G2/M transition checkpoint • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of G0 to G1 transition • transcription by RNA polymerase II • mitotic G2 DNA damage checkpoint signaling • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sydd yn cael eu codio yn y corff dynol gan y genyn BRCA1 yw BRCA1 a elwir hefyd yn breast cancer 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi eu lleoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.31.
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mae'r un genyn oedd hi. Hefyd Mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BRCA1.
IRIS
PSCP
BRCAI
BRCC1
FANCS
PNCA4
RNF53
BROVCA1
PPP1R53
"Diagnostic markers for the detection of ovarian cancer in BRCA1 mutation carriers. ". PLoS One . 2017. PMID 29244844 . "Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. ". Nat Genet . 2017. PMID 29058716 . "Ovarian Aging in Women With BRCA Germline Mutations. ". J Clin Endocrinol Metab . 2017. PMID 28938488 . "Prevalent somatic BRCA1 mutations shape clinically relevant genomic patterns of nasopharyngeal carcinoma in Southeast Europe. ". Int J Cancer . 2018. PMID 28857155 . "Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers. ". Cancer Lett . 2017. PMID 28377179 .
↑ "Human PubMed Reference:" .
