BCL2A1

BCL2A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2VM6, 3I1H, 3MQP, 4ZEQ
Dynodwyr
Cyfenwau	BCL2A1, ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1, BCL2 related protein A1
Dynodwyr allanol	OMIM: 601056 HomoloGene: 2988 GeneCards: BCL2A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • channel activity • protein homodimerization activity • protein heterodimerization activity • BH domain binding Cydrannau o'r gell • cytoplasm • mitochondrial outer membrane Prosesau biolegol • GO:0097285 apoptotic process • regulation of apoptotic process • negative regulation of apoptotic process • release of cytochrome c from mitochondria • GO:1990613 mitochondrial fusion • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of apoptotic process • transmembrane transport • extrinsic apoptotic signaling pathway in absence of ligand • GO:0010260 heneiddio • cerebral cortex development • negative regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	597	n/a
Ensembl	ENSG00000140379	n/a
UniProt	Q16548	n/a
RefSeq (mRNA)	NM_004049 NM_001114735	n/a
RefSeq (protein)	NP_001108207 NP_004040	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCL2A1 yw BCL2A1 a elwir hefyd yn BCL2 related protein A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q25.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCL2A1.

• GRS
• ACC1
• ACC2
• BFL1
• ACC-1
• ACC-2
• HBPA1
• BCL2L5

Llyfryddiaeth

• "Anti-apoptotic BFL-1 is the major effector in activation-induced human mast cell survival. ". PLoS One. 2012. PMID 22720045.
• "Tax protein-induced expression of antiapoptotic Bfl-1 protein contributes to survival of human T-cell leukemia virus type 1 (HTLV-1)-infected T-cells. ". J Biol Chem. 2012. PMID 22553204.
• "Role of the pro-survival molecule Bfl-1 in melanoma. ". Int J Biochem Cell Biol. 2015. PMID 25486183.
• "BCL2A1 is a potential biomarker for postoperative seizure control in patients with low-grade gliomas. ". CNS Neurosci Ther. 2013. PMID 23841872.
• "µ-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis.". PLoS One. 2012. PMID 22745672.