BCL2

BCL2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG
Dynodwyr
Cyfenwau	BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2
Dynodwyr allanol	OMIM: 151430 HomoloGene: 527 GeneCards: BCL2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein phosphatase binding; • transcription factor binding; • protein phosphatase 2A binding; • channel inhibitor activity; • protein homodimerization activity; • channel activity; • protease binding; • GO:0001948, GO:0016582 protein binding; • sequence-specific DNA binding; • BH3 domain binding; • identical protein binding; • protein heterodimerization activity; • ubiquitin protein ligase binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • nuclear membrane; • bilen; • mitocondria; • cnewyllyn cell; • mitochondrial membranes; • myelin sheath; • mitochondrial outer membrane; • Reticwlwm endoplasmig; • pore complex; • integral component of membrane; • intracellular anatomical structure; • endoplasmic reticulum membrane; • nucleoplasm; • GO:0009327 protein-containing complex;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • intrinsic apoptotic signaling pathway in response to oxidative stress; • ureteric bud development; • renal system process; • organ growth; • T cell differentiation in thymus; • lymphocyte homeostasis; • response to steroid hormone; • GO:0048554 positive regulation of catalytic activity; • ear development; • glomerulus development; • post-embryonic development; • cellular response to DNA damage stimulus; • T cell homeostasis; • negative regulation of ossification; • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle; • positive regulation of smooth muscle cell migration; • regulation of protein localization; • T cell differentiation; • B cell lineage commitment; • response to ischemia; • regulation of mitochondrial membrane permeability; • humoral immune response; • defense response to virus; • mesenchymal cell development; • positive regulation of multicellular organism growth; • animal organ morphogenesis; • developmental pigmentation; • hair follicle morphogenesis; • B cell differentiation; • cell population proliferation; • metanephros development; • melanocyte differentiation; • negative regulation of autophagy; • positive regulation of neuron maturation; • negative regulation of myeloid cell apoptotic process; • cellular response to hypoxia; • pigment granule organization; • negative regulation of cell population proliferation; • B cell receptor signaling pathway; • cellular response to organic substance; • regulation of apoptotic process; • response to cytokine; • cellular response to glucose starvation; • regulation of protein stability; • ossification; • positive regulation of melanocyte differentiation; • axon regeneration; • kidney development; • actin filament organization; • thymus development; • negative regulation of intrinsic apoptotic signaling pathway; • negative regulation of apoptotic signaling pathway; • response to nicotine; • spleen development; • endoplasmic reticulum calcium ion homeostasis; • positive regulation of skeletal muscle fiber development; • GO:0001306 response to oxidative stress; • lymphoid progenitor cell differentiation; • positive regulation of peptidyl-serine phosphorylation; • CD8-positive, alpha-beta T cell lineage commitment; • reactive oxygen species metabolic process; • negative regulation of retinal cell programmed cell death; • branching involved in ureteric bud morphogenesis; • gland morphogenesis; • positive regulation of cell growth; • positive regulation of B cell proliferation; • negative regulation of cell growth; • response to gamma radiation; • positive regulation of intrinsic apoptotic signaling pathway; • response to toxic substance; • digestive tract morphogenesis; • neuron apoptotic process; • male gonad development; • regulation of protein heterodimerization activity; • regulation of glycoprotein biosynthetic process; • regulation of viral genome replication; • female pregnancy; • negative regulation of mitochondrial depolarization; • GO:0016576 protein dephosphorylation; • protein polyubiquitination; • cellular calcium ion homeostasis; • B cell homeostasis; • behavioral fear response; • oocyte development; • regulation of cell-matrix adhesion; • response to iron ion; • negative regulation of cell migration; • regulation of autophagy; • positive regulation of developmental pigmentation; • developmental growth; • regulation of transmembrane transporter activity; • ovarian follicle development; • regulation of gene expression; • negative regulation of calcium ion transport into cytosol; • negative regulation of osteoblast proliferation; • homeostasis of number of cells within a tissue; • pigmentation; • response to radiation; • GO:0048552 regulation of catalytic activity; • peptidyl-threonine phosphorylation; • regulation of protein homodimerization activity; • negative regulation of anoikis; • response to hydrogen peroxide; • T cell lineage commitment; • cochlear nucleus development; • leukocyte homeostasis; • regulation of programmed cell death; • regulation of calcium ion transport; • axonogenesis; • negative regulation of cellular pH reduction; • response to glucocorticoid; • regulation of cell cycle; • regulation of mitochondrial membrane potential; • melanin metabolic process; • focal adhesion assembly; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • B cell proliferation; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • immune system development; • apoptotic mitochondrial changes; • GO:0035404 peptidyl-serine phosphorylation; • regulation of nitrogen utilization; • GO:0000767 cell morphogenesis; • positive regulation of cell population proliferation; • negative regulation of reactive oxygen species metabolic process; • response to UV-B; • regulation of developmental pigmentation; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • extrinsic apoptotic signaling pathway via death domain receptors; • release of cytochrome c from mitochondria; • negative regulation of mitotic cell cycle; • extrinsic apoptotic signaling pathway in absence of ligand; • GO:0097285 apoptotic process; • transmembrane transport; • intrinsic apoptotic signaling pathway in response to DNA damage; • growth; • cell-cell adhesion; • cytokine-mediated signaling pathway; • negative regulation of apoptotic process; • hemopoiesis; • regulation of growth; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologau
	596
	n/a
	ENSG00000171791
	n/a
	P10415
	n/a
	NM_000633; NM_000657
	n/a
	NP_000624; NP_000648
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCL2 yw BCL2 a elwir hefyd yn BCL2, apoptosis regulator (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.33.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCL2.

Bcl-2
PPP1R50

Llyfryddiaeth[golygu | golygu cod]

"Therapeutics targeting Bcl-2 in hematological malignancies. ". Biochem J. 2017. PMID 29061914.
"Induction of the chromosomal translocation t(14;18) by targeting the BCL-2 locus with specific binding I-125-labeled triplex-forming oligonucleotides. ". Mutat Res. 2017. PMID 28985947.
"Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients. ". Blood. 2017. PMID 28972015.
"Effects of genomic disruption of a guanine quadruplex in the 5' UTR of the Bcl-2 mRNA in melanoma cells. ". FEBS Lett. 2017. PMID 28940390.
"Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence.". Chembiochem. 2017. PMID 28805284.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] BCL2 - Cronfa NCBI

[1]

[2]