BCAR1

BCAR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WYX, 3T6G
Dynodwyr
Cyfenwau	BCAR1, CAS, CAS1, CASS1, CRKAS, P130Cas, Cas family scaffolding protein, Cas family scaffold protein, BCAR1 scaffold protein, Cas family member
Dynodwyr allanol	OMIM: 602941 HomoloGene: 7674 GeneCards: BCAR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SH3 domain binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • signal transducer activity Cydrannau o'r gell • cytoplasm • cytosol • focal adhesion • Cellbilen • cell junction • actin cytoskeleton • lamellipodium • ruffle Prosesau biolegol • regulation of apoptotic process • B cell receptor signaling pathway • G protein-coupled receptor signaling pathway • GO:1901047 insulin receptor signaling pathway • neurotrophin TRK receptor signaling pathway • epidermal growth factor receptor signaling pathway • actin filament organization • positive regulation of cell migration • cellular response to hepatocyte growth factor stimulus • antigen receptor-mediated signaling pathway • Cellraniad • positive regulation of endothelial cell migration • vascular endothelial growth factor receptor signaling pathway • cell adhesion • regulation of cell growth • cell chemotaxis • integrin-mediated signaling pathway • platelet-derived growth factor receptor signaling pathway • cell population proliferation • T cell receptor signaling pathway • hepatocyte growth factor receptor signaling pathway • cell migration • GO:0072468 signal transduction • actin filament reorganization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9564	n/a
Ensembl	ENSG00000050820 ENSG00000285460	n/a
UniProt	P56945	n/a
RefSeq (mRNA)	NM_001170714 NM_001170715 NM_001170716 NM_001170717 NM_001170718 NM_001170719 NM_001170720 NM_001170721 NM_014567	n/a
RefSeq (protein)	NP_001164185 NP_001164186 NP_001164187 NP_001164188 NP_001164189 NP_001164190 NP_001164191 NP_001164192 NP_055382	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCAR1 yw BCAR1 a elwir hefyd yn Breast cancer anti-estrogen resistance protein 1 a BCAR1, Cas family scaffolding protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCAR1.

• CAS
• CAS1
• CASS1
• CRKAS
• P130Cas

Llyfryddiaeth

• "Identification of Novel Crk-associated Substrate (p130Cas) Variants with Functionally Distinct Focal Adhesion Kinase Binding Activities. ". J Biol Chem. 2015. PMID 25805500.
• "p130Cas scaffolds the signalosome to direct adaptor-effector cross talk during Kaposi's sarcoma-associated herpesvirus trafficking in human microvascular dermal endothelial cells. ". J Virol. 2014. PMID 25253349.
• "The focal adhesion targeting domain of p130Cas confers a mechanosensing function. ". J Cell Sci. 2017. PMID 28223315.
• "A truncated phosphorylated p130Cas substrate domain is sufficient to drive breast cancer growth and metastasis formation in vivo. ". Tumour Biol. 2016. PMID 26867768.
• "Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant.". Circ Cardiovasc Genet. 2015. PMID 26276885.