ARHGEF4

ARHGEF4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DX1, 2PZ1, 3NMX, 3NMZ
Dynodwyr
Cyfenwau	ARHGEF4, ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39
Dynodwyr allanol	OMIM: 605216 HomoloGene: 49414 GeneCards: ARHGEF4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein domain specific binding • guanyl-nucleotide exchange factor activity Cydrannau o'r gell • cytoplasm • ruffle membrane • cytosol • Cellbilen • cell projection • bilen Prosesau biolegol • filopodium assembly • regulation of Rho protein signal transduction • GO:0007243 intracellular signal transduction • regulation of small GTPase mediated signal transduction • lamellipodium assembly • positive regulation of apoptotic process • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	50649	n/a
Ensembl	ENSG00000136002	n/a
UniProt	Q9NR80	n/a
RefSeq (mRNA)	NM_015320 NM_032995 NM_001367493 NM_001375900 NM_001375901 NM_001375902 NM_001375903 NM_001375904 NM_001395416	n/a
RefSeq (protein)	NP_056135 NP_001354422 NP_001362829 NP_001362830 NP_001362831 NP_001362832 NP_001362833	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGEF4 yw ARHGEF4 a elwir hefyd yn Rho guanine nucleotide exchange factor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGEF4.

• ASEF
• GEF4
• STM6
• ASEF1

Llyfryddiaeth

• "Structural basis for the recognition of Asef by adenomatous polyposis coli. ". Cell Res. 2012. PMID 21788986.
• "Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF. ". J Cell Sci. 2008. PMID 18653540.
• "The RAC specific guanine nucleotide exchange factor Asef functions downstream from TEL-AML1 to promote leukaemic transformation. ". Leuk Res. 2010. PMID 19628279.
• "Mutated APC and Asef are involved in the migration of colorectal tumour cells. ". Nat Cell Biol. 2003. PMID 12598901.
• "Association of Asef and Cdc42 expression to tubular injury in diseased human kidney.". J Investig Med. 2013. PMID 23941980.