ARHGDIB

ARHGDIB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DS6
Dynodwyr
Cyfenwau	ARHGDIB, D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2, Rho GDP dissociation inhibitor beta
Dynodwyr allanol	OMIM: 602843 HomoloGene: 20318 GeneCards: ARHGDIB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • Rho GDP-dissociation inhibitor activity • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • extracellular exosome • Cytosgerbwd • GO:0016023 cytoplasmic vesicle Prosesau biolegol • negative regulation of cell adhesion • regulation of actin cytoskeleton reorganization • negative regulation of trophoblast cell migration • multicellular organism development • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cellular response to redox state • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • GO:0048552 regulation of catalytic activity • Rho protein signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	397	n/a
Ensembl	ENSG00000111348	n/a
UniProt	P52566	n/a
RefSeq (mRNA)	NM_001175 NM_001321420 NM_001321421 NM_001321422 NM_001321423	n/a
RefSeq (protein)	NP_001166 NP_001308349 NP_001308350 NP_001308351 NP_001308352	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGDIB yw ARHGDIB a elwir hefyd yn Rho GDP dissociation inhibitor beta a Rho GDP-dissociation inhibitor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p12.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGDIB.

• D4
• GDIA2
• GDID4
• LYGDI
• Ly-GDI
• RAP1GN1
• RhoGDI2

Llyfryddiaeth

• "Apoptosis‑independent cleavage of RhoGDIβ at Asp19 during PMA‑stimulated differentiation of THP‑1 cells to macrophages. ". Mol Med Rep. 2017. PMID 28260067.
• "NMR characterization of weak interactions between RhoGDI2 and fragment screening hits. ". Biochim Biophys Acta. 2017. PMID 27721047.
• "Radiation-Induced RhoGDIβ Cleavage Leads to Perturbation of Cell Polarity: A Possible Link to Cancer Spreading. ". J Cell Physiol. 2016. PMID 26919575.
• "RNA interference-mediated knockdown of RhoGDI2 induces the migration and invasion of human lung cancer A549 cells via activating the PI3K/Akt pathway. ". Tumour Biol. 2015. PMID 25266803.
• "Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma.". Int J Mol Med. 2014. PMID 24788627.