ARHGDIA

ARHGDIA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CC0, 1FSO, 1FST, 1FT0, 1FT3, 1HH4, 1KMT, 1QVY, 1RHO, 2BXW, 2JHS, 2JHT, 2JHU, 2JHV, 2JHW, 2JHX, 2JHY, 2JHZ, 2JI0, 2N80
Dynodwyr
Cyfenwau	ARHGDIA, GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1, Rho GDP dissociation inhibitor alpha
Dynodwyr allanol	OMIM: 601925 HomoloGene: 908 GeneCards: ARHGDIA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • Rho GDP-dissociation inhibitor activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cytosol • extracellular exosome • Cytosgerbwd • bilen Prosesau biolegol • negative regulation of cell adhesion • regulation of actin cytoskeleton reorganization • negative regulation of apoptotic process • positive regulation of axonogenesis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of axonogenesis • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • semaphorin-plexin signaling pathway • GO:0048552 regulation of catalytic activity • Rho protein signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	396	n/a
Ensembl	ENSG00000141522	n/a
UniProt	P52565	n/a
RefSeq (mRNA)	NM_001185077 NM_001185078 NM_001301240 NM_001301241 NM_001301242 NM_001301243 NM_004309	n/a
RefSeq (protein)	NP_001172006 NP_001172007 NP_001288169 NP_001288170 NP_001288171 NP_001288172 NP_004300	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGDIA yw ARHGDIA a elwir hefyd yn Rho GDP-dissociation inhibitor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGDIA.

• GDIA1
• NPHS8
• RHOGDI
• RHOGDI-1
• HEL-S-47e

Llyfryddiaeth

• "Proteome analysis of irradiated endothelial cells reveals persistent alteration in protein degradation and the RhoGDI and NO signalling pathways. ". Int J Radiat Biol. 2017. PMID 28697312.
• "Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation. ". J Biol Chem. 2016. PMID 26719334.
• "Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells. ". Int J Oncol. 2014. PMID 24859471.
• "Overexpression of RhoGDI, a novel predictor of distant metastasis, promotes cell proliferation and migration in hepatocellular carcinoma. ". FEBS Lett. 2014. PMID 24374343.
• "Loss of RhoGDI is a novel independent prognostic factor in hepatocellular carcinoma.". Int J Clin Exp Pathol. 2013. PMID 24228117.