ARHGAP35

ARHGAP35
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K85, 3C5H, 3FK2
Dynodwyr
Cyfenwau	ARHGAP35, GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP, Rho GTPase activating protein 35
Dynodwyr allanol	OMIM: 605277 HomoloGene: 35136 GeneCards: ARHGAP35
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • GTP binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • phospholipid binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GO:0006184 GTPase activity • nucleotide binding • lipid binding Cydrannau o'r gell • cytoplasm • cytosol • actin cytoskeleton • cnewyllyn cell • Cytosgerbwd • cell projection • Cellbilen • bilen • ciliary basal body Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • negative regulation of Rho protein signal transduction • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • neural tube closure • regulation of cell shape • forebrain development • camera-type eye development • GO:0045996 negative regulation of transcription, DNA-templated • regulation of small GTPase mediated signal transduction • GO:0072468 signal transduction • negative regulation of vascular permeability • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • axon guidance • axonal fasciculation • regulation of actin polymerization or depolymerization • positive regulation of neuron projection development • cell migration • central nervous system neuron axonogenesis • mammary gland development • establishment or maintenance of actin cytoskeleton polarity • cellular response to extracellular stimulus • regulation of actin cytoskeleton organization • wound healing, spreading of cells • positive regulation of cilium assembly • regulation of axonogenesis • neuron projection guidance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2909	n/a
Ensembl	ENSG00000160007	n/a
UniProt	Q9NRY4	n/a
RefSeq (mRNA)	NM_004491 NM_024342	n/a
RefSeq (protein)	NP_004482	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGAP35 yw ARHGAP35 a elwir hefyd yn Rho GTPase activating protein 35 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGAP35.

• GRF-1
• GRLF1
• P190A
• P190-A
• p190RhoGAP
• p190ARhoGAP

Llyfryddiaeth

• "Glucocorticoid receptor DNA binding factor 1 expression and osteosarcoma prognosis. ". Tumour Biol. 2014. PMID 25185653.
• "Rho GTPase-activating protein 35 rs1052667 polymorphism and osteosarcoma risk and prognosis. ". Biomed Res Int. 2014. PMID 25136583.
• "p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells. ". Int J Oncol. 2013. PMID 24043274.
• "Mitotic down-regulation of p190RhoGAP is required for the successful completion of cytokinesis. ". J Biol Chem. 2010. PMID 20534586.
• "p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.". Gene. 2000. PMID 11054565.