ABO

ABO
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1LZ0, 1LZ7, 1LZI, 1LZJ, 1R7T, 1R7U, 1R7V, 1R7X, 1R7Y, 1R80, 1R81, 1R82, 1WSZ, 1WT0, 1WT1, 1WT2, 1WT3, 1XZ6, 1ZHJ, 1ZI1, 1ZI3, 1ZI4, 1ZI5, 1ZIZ, 1ZJ0, 1ZJ1, 1ZJ2, 1ZJ3, 1ZJO, 1ZJP, 2A8U, 2A8W, 2I7B, 2O1F, 2O1G, 2O1H, 2PGV, 2RIT, 2RIX, 2RIY, 2RIZ, 2RJ0, 2RJ1, 2RJ4, 2RJ5, 2RJ6, 2RJ7, 2RJ8, 2RJ9, 2Y7A, 3I0C, 3I0D, 3I0E, 3I0F, 3I0G, 3I0H, 3I0I, 3I0J, 3I0K, 3I0L, 3IOH, 3IOI, 3IOJ, 3SX3, 3SX5, 3SX7, 3SX8, 3SXA, 3SXB, 3SXC, 3SXD, 3SXE, 3SXG, 3U0X, 3U0Y, 3V0L, 3V0M, 3V0N, 3V0O, 3V0P, 3V0Q, 3ZGF, 4C2S, 4KC1, 4KC2, 4KC4, 3ZGG, 4FQW, 4FRA, 4FRB, 4FRD, 4FRE, 4FRH, 4FRL, 4FRO, 4FRP, 4FRQ, 4GBP, 4KXO, 4Y62, 4Y63, 4Y64, 5BXC, 5C1G, 5C1H, 5C1L, 5C36, 5C38, 5C3A, 5C3B, 5C3D, 5C47, 5C48, 5C49, 5C4B, 5C4C, 5C4D, 5C4E, 5C4F, 5C8R, 5CMI, 2PGY
Dynodwyr
Cyfenwau	ABO, A3GALNT, A3GALT1, GTB, NAGAT, ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase), alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
Dynodwyr allanol	OMIM: 110300 HomoloGene: 69306 GeneCards: ABO
EC number	2.4.1.37 2.4.1.40, 2.4.1.37
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • hexosyltransferase activity • metal ion binding • fucosylgalactoside 3-alpha-galactosyltransferase activity • glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity • glycosyltransferase activity • nucleotide binding • GO:0003823, GO:0051635 antigen binding • manganese ion binding Cydrannau o'r gell • integral component of membrane • extracellular region • Golgi cisterna membrane • bilen • Golgi apparatus • fesigl Prosesau biolegol • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • glycolipid biosynthetic process • lipid glycosylation • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	28	n/a
Ensembl	ENSG00000175164 ENSG00000281879	n/a
UniProt	P16442	n/a
RefSeq (mRNA)	NM_020469	n/a
RefSeq (protein)	NP_065202	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ABO yw ABO a elwir hefyd yn alpha 1-3-N-acetylgalactosaminyltransferase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q34.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ABO.

• GTB
• NAGAT
• A3GALNT
• A3GALT1

Llyfryddiaeth

• "An exonic missense mutation c.28G>A is associated with weak B blood group by affecting RNA splicing of the ABO gene. ". Transfusion. 2017. PMID 28653406.
• "Protein NMR Studies of Substrate Binding to Human Blood Group A and B Glycosyltransferases. ". Chembiochem. 2017. PMID 28256109.
• "Glycosyltransfer in mutants of putative catalytic residue Glu303 of the human ABO(H) A and B blood group glycosyltransferases GTA and GTB proceeds through a labile active site. ". Glycobiology. 2017. PMID 27979997.
• "Association study of polymorphisms in the ABO gene with ischemic stroke in the Chinese population. ". BMC Neurol. 2016. PMID 27542834.
• "Protein stability changes of the novel p.Arg180Cys mutant A glycosyltransferase resulted in a weak A phenotype.". Vox Sang. 2016. PMID 27538125.