FGA

FGA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BBR, 1DM4, 1FPH, 1FZA, 1FZB, 1FZC, 1FZD, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 1YCP, 2A45, 2FFD, 2H43, 2HLO, 2HOD, 2HPC, 2OYH, 2OYI, 2Q9I, 2XNX, 2XNY, 2Z4E, 3AT0, 3BVH, 3E1I, 3GHG, 3H32, 3HUS, 4F27, 5CFA
Dynodwyr
Cyfenwau	FGA, Fib2, fibrinogen alpha chain
Dynodwyr allanol	OMIM: 134820 HomoloGene: 428 GeneCards: FGA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-macromolecule adaptor activity • structural molecule activity • metal ion binding • GO:0001948, GO:0016582 protein binding • signaling receptor binding • cell adhesion molecule binding Cydrannau o'r gell • platelet alpha granule • extracellular vesicle • Cellbilen • fibrinogen complex • extracellular region • cell surface • cell cortex • extracellular exosome • platelet alpha granule lumen • external side of plasma membrane • blood microparticle • extracellular space • endoplasmic reticulum lumen Prosesau biolegol • hemostasis • negative regulation of endothelial cell apoptotic process • positive regulation of peptide hormone secretion • protein polymerization • positive regulation of heterotypic cell-cell adhesion • adaptive immune response • fibrinolysis • immune system process • platelet degranulation • blood coagulation • extracellular matrix organization • response to calcium ion • positive regulation of substrate adhesion-dependent cell spreading • blood coagulation, common pathway • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of vasoconstriction • positive regulation of protein secretion • positive regulation of ERK1 and ERK2 cascade • negative regulation of blood coagulation, common pathway • positive regulation of exocytosis • blood coagulation, fibrin clot formation • plasminogen activation • cell-matrix adhesion • innate immune response • platelet aggregation • GO:0072468 signal transduction • induction of bacterial agglutination • platelet activation • toll-like receptor signaling pathway • post-translational protein modification Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2243	n/a
Ensembl	ENSG00000171560	n/a
UniProt	P02671	n/a
RefSeq (mRNA)	NM_000508 NM_021871	n/a
RefSeq (protein)	NP_000499 NP_068657	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGA yw FGA a elwir hefyd yn Fibrinogen alpha chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q31.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGA.

• Fib2

Llyfryddiaeth

• "Unrecognized Fibrinogen A α-Chain Amyloidosis: Results From Targeted Genetic Testing. ". Am J Kidney Dis. 2017. PMID 28359658.
• "Evaluation of serum D-dimer, fibrinogen, and CA19-9 for postoperative monitoring and survival prediction in resectable pancreatic carcinoma. ". World J Surg Oncol. 2017. PMID 28219450.
• "A Case-Control Study of the Association between Polymorphisms in the Fibrinogen Alpha Chain Gene and Schizophrenia. ". Dis Markers. 2017. PMID 28203040.
• "Differential inhibitory action of apixaban on platelet and fibrin components of forming thrombi: Studies with circulating blood and in a platelet-based model of thrombin generation. ". PLoS One. 2017. PMID 28192448.
• "Dysfibrinogenemia-associated novel heterozygous mutation, Shanghai (FGA c.169_180+2 del), leads to N-terminal truncation of fibrinogen Aα chain and impairs fibrin polymerization.". J Clin Pathol. 2017. PMID 27555433.