CTSH

CTSH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BZN
Dynodwyr
Cyfenwau	CTSH, ACC-4, ACC-5, CPSB, minichain, ACC4, ACC5, cathepsin H
Dynodwyr allanol	OMIM: 116820 HomoloGene: 36159 GeneCards: CTSH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase activator activity involved in apoptotic process • cysteine-type peptidase activity • HLA-A specific activating MHC class I receptor activity • endopeptidase activity • GO:0001948, GO:0016582 protein binding • cysteine-type endopeptidase activator activity involved in apoptotic process • cysteine-type endopeptidase activity • aminopeptidase activity • serine-type endopeptidase activity • hydrolase activity • thyroid hormone binding • GO:0070122 peptidase activity Cydrannau o'r gell • cytosol • alveolar lamellar body • lysosome • extracellular exosome • multivesicular body lumen • extracellular region • extracellular space • secretory granule lumen • intracellular membrane-bounded organelle • tertiary granule lumen • ficolin-1-rich granule lumen • cytoplasmic ribonucleoprotein granule • collagen-containing extracellular matrix Prosesau biolegol • surfactant homeostasis • antigen processing and presentation • adaptive immune response • bradykinin catabolic process • response to retinoic acid • membrane protein proteolysis • positive regulation of cell migration • ERK1 and ERK2 cascade • zymogen activation • neuropeptide catabolic process • positive regulation of epithelial cell migration • positive regulation of apoptotic signaling pathway • negative regulation of apoptotic process • proteolysis • positive regulation of angiogenesis • positive regulation of peptidase activity • GO:1901313 positive regulation of gene expression • protein destabilization • cellular response to thyroid hormone stimulus • positive regulation of cell population proliferation • immune response-regulating signaling pathway • proteolysis involved in cellular protein catabolic process • metanephros development • dichotomous subdivision of terminal units involved in lung branching • T cell mediated cytotoxicity • GO:0097285 apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • neutrophil degranulation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1512	n/a
Ensembl	ENSG00000103811	n/a
UniProt	P09668	n/a
RefSeq (mRNA)	NM_004390 NM_148979 NM_001319137	n/a
RefSeq (protein)	NP_001306066 NP_004381	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTSH yw CTSH a elwir hefyd yn Cathepsin H (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q25.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTSH.

• ACC4
• ACC5
• CPSB
• ACC-4
• ACC-5

Llyfryddiaeth

• "Functional relevance for type 1 diabetes mellitus-associated genetic variants by using integrative analyses. ". Hum Immunol. 2015. PMID 26429317.
• "Polymorphisms in the CTSH gene may influence the progression of diabetic retinopathy: a candidate-gene study in the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987). ". Graefes Arch Clin Exp Ophthalmol. 2015. PMID 26245339.
• "The influence of differential processing of procathepsin H on its aminopeptidase activity, secretion and subcellular localization in human cell lines. ". Eur J Cell Biol. 2012. PMID 22704610.
• "Serum cathepsin H as a potential prognostic marker in patients with colorectal cancer. ". Int J Biol Markers. 2004. PMID 15646835.
• "Human cathepsin H: deletion of the mini-chain switches substrate specificity from aminopeptidase to endopeptidase.". Biol Chem. 2003. PMID 14515996.