ARAF

ARAF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WXM, 2MSE
Dynodwyr
Cyfenwau	ARAF, A-Raf proto-oncogene, serine/threonine kinase, A-RAF, ARAF1, PKS2, RAFA1, Serine/threonine-protein kinase A-Raf
Dynodwyr allanol	OMIM: 311010 HomoloGene: 1249 GeneCards: ARAF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • MAP kinase kinase kinase activity • mitogen-activated protein kinase kinase binding Cydrannau o'r gell • mitocondria • cytosol • cydran cellog Prosesau biolegol • GO:0007243 intracellular signal transduction • regulation of TOR signaling • phosphorylation • negative regulation of apoptotic process • positive regulation of peptidyl-serine phosphorylation • MAPK cascade • protein phosphorylation • regulation of proteasomal ubiquitin-dependent protein catabolic process • GO:0072468 signal transduction • multicellular organism development • negative regulation of signal transduction • cell differentiation • positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	369	n/a
Ensembl	ENSG00000078061	n/a
UniProt	P10398 Q96II5	n/a
RefSeq (mRNA)	NM_001256196 NM_001256197 NM_001654	n/a
RefSeq (protein)	NP_001243125 NP_001243126 NP_001645 NP_001243125.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARAF yw ARAF a elwir hefyd yn A-Raf proto-oncogene, serine/threonine kinase ac ARAF protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARAF.

• PKS2
• A-RAF
• ARAF1
• RAFA1

Llyfryddiaeth

• "A-Raf: A new star of the family of raf kinases. ". Crit Rev Biochem Mol Biol. 2015. PMID 26508523.
• "Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration. ". Sci Signal. 2014. PMID 25097033.
• "Somatic activating ARAF mutations in Langerhans cell histiocytosis. ". Blood. 2014. PMID 24652991.
• "Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites. ". J Biol Chem. 2008. PMID 18662992.
• "Identification of key residues in the A-Raf kinase important for phosphoinositide lipid binding specificity.". Biochemistry. 2005. PMID 15736953.